Product Name :
1,2-benzoxazol-3-ylmethanesulfonamide (CAS 68291-97-4)
Synonym :
Zonisamide
Application :
1,2-benzoxazol-3-ylmethanesulfonamide is an anticonvulsant blocker of voltage-sensitive T-type Ca2+ and Na+ channels
CAS:
68291-97-4
Purity:
Molecular Weight:
212.23
Formula :
C8H8N2O3S
Physical state:
Solid
solubility :
Soluble in water (10 mM), DMSO (100 mM), 1.1eq. 2-Aminoacetamide site Trifluoromethylsulfonamide Data Sheet NaOH (100 mM), ethanol (25 mM), methanol, and ethyl acetate.
Shipping Condition :
Store at room temperature
Melting point:
162-167° C
SMILES:
C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
References:
:Zonisamide: chemistry, mechanism of action, and pharmacokinetics. | Leppik, IE. 2004. Seizure. 13 Suppl 1: S5-9; discussion S10. PMID: 15511691Drug monitoring and toxicology: a procedure for the monitoring of levetiracetam and zonisamide by HPLC-UV. | Juenke, J., et al. 2006. J Anal Toxicol. 30: 27-30. PMID: 16620528Simultaneous determination of lamotrigine, zonisamide, and carbamazepine in human plasma by high-performance liquid chromatography. | Greiner-Sosanko, E., et al. 2007. Biomed Chromatogr. 21: 225-8. PMID: 17230449Effects of zonisamide on experimental tremors in rats. | Miwa, H., et al. 2008. Parkinsonism Relat Disord. 14: 33-6. PMID: 17587636Disposition and safety of zonisamide after intravenous and oral single dose and oral multiple dosing in normal hound dogs. | Boothe, DM. and Perkins, J. 2008. J Vet Pharmacol Ther. 31: 544-53. PMID: 19000278Zonisamide increases dopamine turnover in the striatum of mice and common marmosets treated with MPTP. | Yabe, H., et al. 2009. J Pharmacol Sci. 110: 64-8. PMID: 19403994The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance. | Sonsalla, PK., et al. 2010. Exp Neurol. 221: 329-34. PMID: 19948168Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD. | Kawajiri, S., et al. 2010. Neurosci Lett. 481: 88-91. PMID: 20600601Post-treatment with voltage-gated Na(+) channel blocker attenuates kainic acid-induced apoptosis in rat primary hippocampal neurons. | Das, A., et al. 2010. Neurochem Res. 35: 2175-83. PMID: 21127971Zonisamide ameliorates levodopa-induced dyskinesia and reduces expression of striatal genes in Parkinson model rats. | Oki, M., et al. 2017. Neurosci Res. 122: 45-50. PMID: 28577977Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress. | Tian, JH., et al. 2021. Acta Pharmacol Sin. 42: 393-403. PMID: 32647341Zonisamide alleviates cardiac hypertrophy in rats by increasing Hrd1 expression and inhibiting endoplasmic reticulum stress. | Wu, Q., et al. 2021. Acta Pharmacol Sin. 42: 1587-1597. PMID: 33495518Presumed zonisamide-induced blood dyscrasias in four dogs. | Brandifino, M., et al. 2022. J Vet Emerg Crit Care (San Antonio). 32: 805-811. PMID: 35739607
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