UNAM, 54059 Estado de M ico, Mexico c Department of Physiology, Biophysics and Neuroscience, Center for Research and Sophisticated Research, National Polytechnic Institute (Cinvestav-IPN), 07360 M ico, DF, Mexico d Laboratory of Renal Pathophysiology, Department of Nephrology, Instituto Nacional de Cardiolog “Ignacio Ch ez”, 14080 M ico, DF, Mexicob aart ic l e i nf oArticle history: Received 31 August 2013 Accepted 5 September 2013 Search phrases: Oxidative stress Bifunctional antioxidant Nrf2 Mitochondrial dysfunction Renal hemodynamics Nephrotoxicitya b s t r a c tFor years, there have already been studies based on the use of organic compounds plant-derived as possible therapeutic agents for various diseases in humans. Curcumin is often a phenolic compound extracted from Curcuma longa rhizome normally utilised in Asia as a spice, pigment and additive. In traditional medicine of India and China, curcumin is viewed as as a therapeutic agent utilised in many foods. Various research have shown that curcumin has broad biological functions specifically antioxidant and antiinflammatory. In reality, it has been established that curcumin is often a bifunctional antioxidant; it exerts antioxidant activity in a direct and an indirect way by scavenging reactive oxygen species and inducing an antioxidant response, respectively. The renoprotective impact of curcumin has been evaluated in a number of experimental models like diabetic nephropathy, chronic renal failure, ischemia and reperfusion and nephrotoxicity induced by compounds for example gentamicin, adriamycin, chloroquine, iron nitrilotriacetate, sodium fluoride, hexavalent chromium and cisplatin. It has been shown not too long ago inside a model of chronic renal failure that curcumin exerts a therapeutic impact; in reality it reverts not merely systemic alterations but additionally glomerular hemodynamic modifications. A further recent obtaining shows that the renoprotective effect of curcumin is related to preservation of function and redox balance of mitochondria. Taking together, these research attribute the protective effect of curcumin inside the kidney to the induction with the master regulator of antioxidant response nuclear factor erythroid-derived two (Nrf2), inhibition of mitochondrial dysfunction, attenuation of inflammatory response, preservation of antioxidant enzymes and prevention of oxidative tension.Buy1201644-34-9 The data presented within this paper identifies curcumin as a promising renoprotective molecule against renal injury.Price of 1445-55-2 2013 The Authors.PMID:23795974 Published by Elsevier B.V. All rights reserved.Contents Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . History and cultivation of Curcuma longa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Curcuminoids and curcumin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Curcumin as a meals additive . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Curcumin: Traditional makes use of in folk medicine and biological properties . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .