F VGLUT1 immunolabeled synaptic terminals in rat striatum ending on spines (A ). Spines (Sp) were recognizable by their tiny size, the presence of spine apparatus (SA), and the absence of mitochondria and microtubules. All VGLUT1 synaptic terminals formed asymmetric synaptic contacts, as recognizable by the thick postsynaptic density (PSD). Within the case of some synaptic contacts, the PSD was perforated (asterisks in C,D). All images are at the same magnification shown in (B).J Comp Neurol. Author manuscript; available in PMC 2014 August 25.Lei et al.PageNIHPA Author Manuscript NIHPA Author Manuscript NIHPA Author ManuscriptJ Comp Neurol. Author manuscript; offered in PMC 2014 August 25.Figure 9.Size frequency distributions for axospinous (AS) and axodendritic (AD) VGLUT1 and VGLUT2 terminals in rat striatum, scaled to their relative abundances.1416444-91-1 uses Lei et al.PageNIHPA Author Manuscript NIHPA Author Manuscript NIHPA Author ManuscriptFigure ten.Images of VGLUT2 immunolabeled synaptic terminals in rat striatum ending on D1 spines (A,C), D1negative spines (B,D), D1 dendrites (E), or D1negative dendrites (F). Spines (Sp) had been recognizable by their compact size, the presence of spine apparatus, and also the absence of mitochondria (M) and microtubules, whilst dendrites (De) were recognizable by their bigger size, the presence of mitochondria and microtubules, plus the absence of spine apparatus. VGLUT2 synaptic terminals formed asymmetric synaptic contacts, asJ Comp Neurol. Author manuscript; readily available in PMC 2014 August 25.Lei et al.Pagerecognizable by the thick postsynaptic density (PSD). All photos are at the same magnification as shown in (F).NIHPA Author Manuscript NIHPA Author Manuscript NIHPA Author ManuscriptJ Comp Neurol. Author manuscript; accessible in PMC 2014 August 25.Lei et al.PageNIHPA Author Manuscript NIHPA Author Manuscript NIHPA Author ManuscriptFigure 11.3-Phenylcyclobutan-1-amine Order Graphs displaying the size frequency distributions of VGLUT2 axospinous (A) and axodendritic (B) synaptic contacts on D1 and D1negative spines and dendrites in striatum, graphed as a function of spatial frequency per terminal variety of a provided size.PMID:23892407 Note that VGLUT2 contacts on D1 spines and dendrites are additional common than on D1negative spines and dendrites, and also the key distinction appears to be within the greater abundance of small terminals on the D1 structures.J Comp Neurol. Author manuscript; accessible in PMC 2014 August 25.Lei et al.PageNIHPA Author Manuscript NIHPA Author Manuscript NIHPA Author ManuscriptFigure 12.Graphs displaying the size frequency distributions for axospinous synaptic input to striatonigral (A) and striatoGPe neurons (B) in rats. For each neuron varieties we applied prior details on the sorts of cortical axospinous inputs (IT and PT) to these two neuron varieties, the size frequency distributions for these two cortical input sorts, the size frequency distribution for axospinous terminals on retrogradely labeled striatonigral and striatoGPe neurons, and the present findings on thalamic input to these striatal neuron forms to derive estimates of your relative abundance of each and every input sort to the two striatal projection neuronJ Comp Neurol. Author manuscript; out there in PMC 2014 August 25.Lei et al.Pagetypes (Lei et al., 2004; Reiner et al., 2010). Note that 62.7 IT and a 37.3 thalamic input yields an extremely close size frequency distribution match for striatonigral neurons. Within the case of striatoGPe neurons, 54.two PT, 20 IT and 25.eight thalamic yields a close approximation for the a.