Product Name :
2,5-Anhydro-D-mannitol (CAS 41107-82-8)
Synonym :
Application :
2,5-Anhydro-D-mannitol is a carbohydrate metabolism regulator
CAS:
41107-82-8
Purity:
Molecular Weight:
164.16
Formula :
C6H12O5
Physical state:
Solid
solubility :
Soluble in methanol, and water (50 mg/ml).
Shipping Condition :
Store at -20° C
Melting point:
101-103° C (lit.)
SMILES:
C([C@@H]1[C@H]([C@@H]([C@H](O1)CO)O)O)O
References:
:2,5-Anhydro-D-mannitol increases hepatocyte calcium: implications for a hepatic hunger stimulus. | Rawson, NE., et al. 2003. Biochim Biophys Acta. 1642: 59-66. (1-Methylcyclopentyl)methanol Chemscene PMID: 12972294Synthesis of anticoagulantly active heparan sulfate proteoglycans by glomerular epithelial cells involves multiple 3-O-sulfotransferase isoforms and a limiting precursor pool. | Girardin, EP., et al. 2005. J Biol Chem. 280: 38059-70. 1809395-84-3 Data Sheet PMID: 16107334Effect of a nonmetabolizable analog of fructose-1,6-bisphosphate on glycolysis and ethanol production in strains of Saccharomyces cerevisiae and Escherichia coli. | Nghiem, NP. and Cofer, TM. 2007. Appl Biochem Biotechnol. 141: 335-47. PMID: 180255602,5-anhydro-D-mannitol acts in liver to initiate feeding. | Tordoff, MG., et al. 1991. Am J Physiol. 261: R283-8. PMID: 1908642SLC2A5 promotes lung adenocarcinoma cell growth and metastasis by enhancing fructose utilization. | Weng, Y., et al. 2018. Cell Death Discov. 4: 38. PMID: 295318352,5-anhydro-D-mannitol: a fructose analogue that increases food intake in rats. | Tordoff, MG., et al. 1988. Am J Physiol. 254: R150-3. PMID: 3122594Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-D-mannitol Analogs. | Rana, N., et al. 2022. Pharmaceutics. 14: PMID: 35456662The PICLS high-throughput screening method for agents extending cellular longevity identifies 2,5-anhydro-D-mannitol as novel anti-aging compound. | Alfatah, M. and Eisenhaber, F. 2023. Geroscience. 45: 141-158. PMID: 35705837Inhibition of gluconeogenesis by 2,5-anhydro-D-mannitol in isolated rat hepatocytes. | Stevens, HC., et al. 1985. Biochim Biophys Acta. 845: 502-6. PMID: 3924119Mechanism of action of 2,5-anhydro-D-mannitol in hepatocytes. Effects of phosphorylated metabolites on enzymes of carbohydrate metabolism. | Riquelme, PT., et al. 1984. J Biol Chem. 259: 5115-23. PMID: 6325420Inhibition of gluconeogenesis and glycogenolysis by 2,5-anhydro-D-mannitol. | Hanson, RL., et al. 1984. J Biol Chem. 259: 218-23. PMID: 6423625Effects of GLP-1 and 2,5-anhydro-D-mannitol on insulin secretion and plasma glucose in mice. | Ahrén, B., et al. 1995. Endocr Res. 21: 583-94. PMID: 7588428Phosphate loading prevents the decrease in ATP and increase in food intake produced by 2,5-anhydro-D-mannitol. | Rawson, NE. and Friedman, MI. 1994. Am J Physiol. 266: R1792-6. PMID: 8024030Induction of Fos-like immunoreactivity (Fos-li) and stimulation of feeding by 2,5-anhydro-D-mannitol (2,5-AM) require the vagus nerve. | Ritter, S., et al. 1994. Brain Res. 646: 53-64. PMID: 8055341Hepatic phosphate trapping, decreased ATP, and increased feeding after 2,5-anhydro-D-mannitol. | Rawson, NE., et al. 1994. Am J Physiol. 266: R112-7. PMID: 8304531Intraportal infusion of 2,5-anhydro-D-mannitol increases afferent activity in the common hepatic vagus branch. | Lutz, TA., et al. 1996. J Auton Nerv Syst. 61: 204-8. PMID: 89463442,5-Anhydro-D-mannitol induces Fos-like immunoreactivity in hindbrain and forebrain: relationship to eating behavior. | Horn, CC. and Friedman, MI. 1998. Brain Res. 779: 17-25. PMID: 9473567
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