Product Name :
2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline (CAS 77094-11-2)
Synonym :
MeIQ
Application :
2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline is a mutagenic heterocyclic amine found in cooked food. 19393-83-0 Data Sheet
CAS:
77094-11-2
Purity:
Molecular Weight:
212.25
Formula :
C12H12N4
Physical state:
Solid
solubility :
Soluble in Methanol
Shipping Condition :
Store at 4° C
Melting point:
>255° C (dec.)
SMILES:
CC1=CC2=C(C=CC=N2)C3=C1N(C(=N3)N)C
References:
:Activation of MeIQ (2-amino-3,4-dimethylimidazo- [4,5-f]quinoline) by sequence variants of recombinant human cytochrome P450 1A2. | Josephy, PD., et al. BuyN-(2-Hydroxyethyl)maleimide 2000. Environ Mol Mutagen. 35: 328-35. PMID: 10861951Covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein in microsomal incubations and isolated rat hepatocytes. | Wallin, H., et al. 1992. Pharmacol Toxicol. 70: 220-5. PMID: 1579548Genotoxic effects of 2-amino-3,4-dimethylimidazo(4,5-f)quinoline (MeIQ) in rats measured by alkaline elution. | Holme, JA., et al. 1991. Mutat Res. 251: 1-6. PMID: 1944367Metabolism of 2-amino-3-methylimidazo[4,5-f]quinoline IQ and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in suspensions of isolated rat-liver cells. | Holme, JA., et al. 1987. Toxicol In Vitro. 1: 175-81. PMID: 20702361[Genotoxicity of fried fish extract, MeIQ and inhibition by green tea antioxidant]. | Liu, XL. 1990. Zhonghua Zhong Liu Za Zhi. 12: 170-3. PMID: 2249586Antimutagenic activity of flavonoids from Sozuku. | Okuno, Y., et al. 2019. Nat Prod Res. 33: 862-865. PMID: 29183163Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]-quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline (MeIQ) by subcellular fractions and cells isolated from small intestine, kidney and liver of the rat. | Holme, JA., et al. 1987. Cell Biol Toxicol. 3: 51-61. PMID: 3148360Modulation of the mutagenic effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in bacteria with rat-liver 9000 x g supernatant or monolayers of rat hepatocytes as an activation system. | Holme, JA., et al. 1988. Mutat Res. 197: 39-49. PMID: 3275882Comparative genotoxic effects of IQ and MeIQ in Salmonella typhimurium and cultured mammalian cells. | Holme, JA., et al. 1987. Mutat Res. 187: 181-90. PMID: 3550445Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx. | Ohgaki, H., et al. 1985. Princess Takamatsu Symp. 16: 97-105. PMID: 3842704Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice. | Suzuki, T., et al. 1996. Mutat Res. 369: 45-9. PMID: 8700181p53 mutations in MeIQ-induced mouse forestomach tumors. | Makino, H., et al. 1997. Nihon Ika Daigaku Zasshi. 64: 39-44. PMID: 9119951Chromosome aberrations induced in mice by chronic feeding of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ). | Ramsey, MJ., et al. 1998. Food Chem Toxicol. 36: 467-74. PMID: 9674954No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue mice. | Nagao, M., et al. 1998. Mutat Res. 400: 251-7. PMID: 9685668
Headquartered in New Jersey, USA, ChemScence is a global leading manufacturer and supplier of building blocks and fine research chemicals. We now have branches in Sweden and India. Our mission is to pave the way for drug discovery by providing the most innovative chemicals with the highest-level quality for a reasonable price.
Our Catalog Products
We deliver an extensive portfolio of products, including Building Blocks,Catalysts&Ligands,Synthetic Reagents,Material Science and ADC Linkers&Protac,.ChemScene now have over 600000 Building Blocks & Intermediates in our catalog and more than 70000 of them are in stock.
For details, please refer to the ChemScene website:https://www.chemscene.com