Product Name :
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (CAS 105650-23-5)
Synonym :
1-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine; PhIP
Application :
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is a derivitized pyridine compound
CAS:
105650-23-5
Purity:
Molecular Weight:
224.26
Formula :
C13H12N4
Physical state:
Solid
solubility :
Soluble in Dimethylformamide, Dimethyl Sulfoxide and Methanol (hot)
Shipping Condition :
Store at 4° C
Melting point:
>300° C (dec.)
SMILES:
CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1N
References:
:Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice. | Buonarati, MH., et al. 91511-38-5 site 4-(1,3-Dioxolan-2-yl)piperidine Purity 1992. Carcinogenesis. 13: 621-7. PMID: 1576715Inflammation does not precede or accompany the induction of preneoplastic lesions in the colon of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-fed rats. | Kühnel, D., et al. 2009. Arch Toxicol. 83: 763-8. PMID: 19212758Reactive carbonyl-scavenging ability of 2-aminoimidazoles: 2-amino-1-methylbenzimidazole and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). | Hidalgo, FJ., et al. 2014. J Agric Food Chem. 62: 12045-51. PMID: 25418848Effects of some cations on the formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a model system. | Yu, D. and Yu, SJ. 2016. Food Chem. 201: 46-51. PMID: 26868546Dual Effects of Creatinine on the Formation of 2-Amino-1-Methyl-6-Phenylimidazo [4,5-b]pyridine (PhIP). | Yu, C., et al. 2018. J Food Sci. 83: 294-299. PMID: 29341141Formation of a creatinine thermal degradation product and its role and participation in the radical pathway of forming the pyridine ring of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). | Zhang, J., et al. 2020. Food Chem. 312: 126083. PMID: 31901823Target-specific micronucleus induction by colon carcinogens: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 1,2-dimethylhydrazine. | Hori, H., et al. 2020. Regul Toxicol Pharmacol. 112: 104578. PMID: 31935482Inhibitory effect of selected hydrocolloids on 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) formation in chemical models and beef patties. | Yang, H., et al. 2021. J Hazard Mater. 402: 123486. PMID: 327074662-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Induced Colon Injury by Disrupting the Intestinal Bacterial Composition and Lipid Metabolic Pathways in Rats. | Zhao, X., et al. 2021. J Agric Food Chem. 69: 437-446. PMID: 33373210Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways. | Zhao, L., et al. 2021. Food Chem Toxicol. 157: 112582. PMID: 34582963Effects of the Deacetylation Degree of Chitosan on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Formation in Chemical Models and Beef Patties. | Zhao, Y., et al. 2021. J Agric Food Chem. 69: 13933-13941. PMID: 34756022Effect of acrolein, a lipid oxidation product, on the formation of the heterocyclic aromatic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in model systems and roasted tilapia fish patties. | Jing, M., et al. 2022. Food Chem X. 14: 100315. PMID: 35774638Synergistic Inhibitory Effects of Selected Amino Acids on the Formation of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in both Benzaldehyde- and Phenylacetaldehyde-Creatinine Model Systems. | Deng, P., et al. 2022. J Agric Food Chem. 70: 10858-10871. PMID: 36007151
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