Product Name :
2-Acetyl-4-tetrahydroxybutylimidazole (CAS 94944-70-4)
Synonym :
1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]ethanone
Application :
2-Acetyl-4-tetrahydroxybutylimidazole is an SP-lyase inhibitor
CAS:
94944-70-4
Purity:
≥95%
Molecular Weight:
230.22
Formula :
C9H14N2O5
Physical state:
Solid
solubility :
Soluble in DI water, DMSO (>5 mg/ml), and PBS pH 7.2 (~0.15 mg/ml).
Shipping Condition :
Store at -20° C
Melting point:
211.02° C (Predicted)
SMILES:
CC(=O)C1=NC=C(N1)[C@H]([C@@H]([C@@H](CO)O)O)O
References:
:Prevention of spontaneous and cyclophosphamide-induced diabetes in non-obese diabetic (NOD) mice with oral 2-acetyl-4-tetrahydroxybutylimidazole (THI), a component of caramel colouring III. Fmoc-Pen(Trt)-OH Chemical name Ir[dF(F)ppy]2(dtbbpy)PF6 Price | Mandel, TE., et al. 1992. Clin Exp Immunol. 88: 414-9. PMID: 1606724Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. | Schwab, SR., et al. 2005. Science. 309: 1735-9. PMID: 16151014Simultaneous quantitation of 2-acetyl-4-tetrahydroxybutylimidazole, 2- and 4-methylimidazoles, and 5-hydroxymethylfurfural in beverages by ultrahigh-performance liquid chromatography-tandem mass spectrometry. | Wang, J. and Schnute, WC. 2012. J Agric Food Chem. 60: 917-21. PMID: 22224586Determination of 4-Methylimidazole and 2-Acetyl-4()- tetrahydroxybutylimidazole in Caramel Color and Processed Foods by LC-MS/MS. | Kim, TR., et al. 2013. Prev Nutr Food Sci. 18: 263-8. PMID: 24551828The effect of 2-acetyl-4-tetrahydroxybutylimidazole on lymphocyte subsets in peripheral blood of the rat. | Gobin, SJ., et al. 1989. Int J Immunopharmacol. 11: 937-46. PMID: 25756042-acetyl-4-tetrahydroxybutylimidazole and 4-methylimidazole in caramel colours, vinegar and beverages in China. | Wang, L., et al. 2015. Food Addit Contam Part B Surveill. 8: 163-8. PMID: 25832559Determination of imidazole derivatives by micellar electrokinetic chromatography combined with solid-phase microextraction using activated carbon-polymer monolith as adsorbent. | Shih, YH., et al. 2016. J Chromatogr A. 1428: 336-45. PMID: 26363948Process-induced formation of imidazoles in selected foods. | Mottier, P., et al. 2017. Food Chem. 228: 381-387. PMID: 28317738Dietary intake assessment of caramel colours and their processing by-products 4-methylimidazole and 2-acetyl-4-tetrahydroxy-butylimidazole for the Chinese population. | Liang, J., et al. 2019. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 36: 1009-1019. PMID: 31100047Pyridoxine supplementation protects mice from suppression of contact hypersensitivity induced by 2-acetyl-4-tetrahydroxybutylimidazole (THI), ultraviolet B radiation (280-320 nm), or cis-urocanic acid. | Reeve, VE., et al. 1995. Am J Clin Nutr. 61: 571-6. PMID: 7872221Suppressive effect of 2-acetyl-4-tetrahydroxybutylimidazole on contact hypersensitivity in the Skh: HR hairless mouse. | Reeve, VE., et al. 1993. Int Arch Allergy Immunol. 102: 101-6. PMID: 8400881Prevention of splenic granuloma formation in adjuvant arthritis by 2-acetyl-4-tetrahydroxybutylimidazole (THI). | Gugasyan, R., et al. 1997. Immunol Lett. 58: 133-8. PMID: 9293393Emigration of mature T cells from the thymus is inhibited by the imidazole-based compound 2-acetyl-4-tetrahydroxybutylimidazole. | Gugasyan, R., et al. 1998. Immunology. 93: 398-404. PMID: 9640251
Headquartered in New Jersey, USA, ChemScence is a global leading manufacturer and supplier of building blocks and fine research chemicals. We now have branches in Sweden and India. Our mission is to pave the way for drug discovery by providing the most innovative chemicals with the highest-level quality for a reasonable price.
Our Catalog Products
We deliver an extensive portfolio of products, including Building Blocks,Catalysts&Ligands,Synthetic Reagents,Material Science and ADC Linkers&Protac,.ChemScene now have over 600000 Building Blocks & Intermediates in our catalog and more than 70000 of them are in stock.
For details, please refer to the ChemScene website:https://www.chemscene.com