Product Name :
2,8-Dihydroxyadenine (CAS 30377-37-8)
Synonym :
6-Amino-7,9-dihydro-2H-purine-2,8(3H)-dione
Application :
CAS:
30377-37-8
Purity:
Molecular Weight:
167.13
Formula :
C5H5N5O2
Physical state:
Solid
solubility :
Soluble in water (0.002 mg/ml at 23° C), and Aqueous Base.
Shipping Condition :
Store at 4° C
Melting point:
>300° C (dec.)
SMILES:
C12=C(NC(=O)N=C1NC(=O)N2)N
References:
:Radiopaque 2,8-dihydroxyadenine lithiasis. Price of 2387561-40-0 | Yagisawa, T., et al. 1999. Int Urol Nephrol. 31: 141-3. PMID: 104819562,8-Dihydroxyadenine renal stones in a 41-year-old man. | Wilkinson, H., et al. 2004. Ann Clin Biochem. 6-Bromo-2-oxaspiro[3.3]heptane site 41: 160-1. PMID: 150258102,8-dihydroxyadenine nephrolithiasis induces developmental stage-specific alterations in gene expression in mouse kidney. | Chen, J., et al. 2010. Urology. 75: 914-22. PMID: 20035974Rapid measurements of 2,8-dihydroxyadenine (2,8-DHA) with a nanostructured electrochemical sensor in 5-fold diluted supernatants of endothelial cells exposed to oxidative stress. | Kathiwala, M., et al. 2010. Analyst. 135: 296-301. PMID: 200987612,8-Dihydroxyadenine uroliths in a dog. | Houston, DM., et al. 2012. J Am Vet Med Assoc. 241: 1348-52. PMID: 23113528An APRT mutation is strongly associated with and likely causative for 2,8-dihydroxyadenine urolithiasis in dogs. | Furrow, E., et al. 2014. Mol Genet Metab. 111: 399-403. PMID: 24359665Recurrent 2,8-dihydroxyadenine nephropathy: a rare but preventable cause of renal allograft failure. | Zaidan, M., et al. 2014. Am J Transplant. 14: 2623-32. PMID: 253072532,8-Dihydroxyadenine Nephropathy Identified as Cause of End-Stage Renal Disease After Renal Transplant. | George, SA., et al. 2017. Exp Clin Transplant. 15: 574-577. PMID: 27447713Adenine phosphoribosyltransferase deficiency and 2, 8-dihydroxyadenine renal stones: A preventable cause of pediatric renal stones and kidney disease. | Parikh, MD., et al. 2019. Saudi J Kidney Dis Transpl. 30: 723-725. PMID: 31249241Urinary 2,8-dihydroxyadenine excretion in patients with adenine phosphoribosyltransferase deficiency, carriers and healthy control subjects. | Runolfsdottir, HL., et al. 2019. Mol Genet Metab. 128: 144-150. PMID: 31378568Cellular and Molecular Mechanisms of Kidney Injury in 2,8-Dihydroxyadenine Nephropathy. | Klinkhammer, BM., et al. 2020. J Am Soc Nephrol. 31: 799-816. PMID: 32086278Are conventional stone analysis techniques reliable for the identification of 2,8-dihydroxyadenine kidney stones? A case series. | Runolfsdottir, HL., et al. 2020. Urolithiasis. 48: 337-344. PMID: 32399606[A Case Report of 2,8-Dihydroxyadenine Urolithiasis]. | Miyachi, S., et al. 2021. Hinyokika Kiyo. 67: 419-421. PMID: 34610707Sodium benzoate attenuates 2,8-dihydroxyadenine nephropathy by inhibiting monocyte/macrophage TNF- alpha expression. | Oshima, Y., et al. 2023. Sci Rep. 13: 3331. PMID: 36849798Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. | Engle, SJ., et al. 1996. Proc Natl Acad Sci U S A. 93: 5307-12. PMID: 8643571
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