Product Name :
2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (CAS 77500-04-0)
Synonym :
3,8-Dimethyl-3H-Imidazo[4,5-f]quinoxalin-2-amine; MeIQx
Application :
2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline is a white meat mutagen, heterocyclic amine colorectal adenoma recurrence. 1,3,6,8-Tetrabromopyrene site
CAS:
77500-04-0
Purity:
Molecular Weight:
213.24
Formula :
C11H11N5
Physical state:
Solid
solubility :
Soluble in DMF, DMSO and Methanol
Shipping Condition :
Store at 4° C
Melting point:
SMILES:
CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)N
References:
:In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in lacI transgenic (Big Blue) mice. | Itoh, T., et al. 2000. Mutat Res. 6-Bromo-5-fluoroisoquinolin-1(2H)-one Order 468: 19-25. PMID: 10863154Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. | Fukushima, S., et al. 2003. Cancer Lett. 191: 35-40. PMID: 12609707Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice. | Masumura, K., et al. 2003. Mutat Res. 541: 91-102. PMID: 14568298Evidence of a threshold-effect for 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline liver carcinogenicity in F344/DuCrj rats. | Murai, T., et al. 2008. Toxicol Pathol. 36: 472-7. PMID: 18413788A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine. | Gu, D., et al. 2010. Chem Res Toxicol. 23: 788-801. PMID: 20192249The presence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in smoked dry bonito (katsuobushi). | Kikugawa, K., et al. 1986. Jpn J Cancer Res. 77: 99-102. PMID: 3082835Identification of acrolein as the reactive carbonyl responsible for the formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). | Hidalgo, FJ., et al. 2021. Food Chem. 343: 128478. PMID: 33158682Effects of Chlorophyll a and b in Reducing Genotoxicity of 2-Amino-3,8-dimethylimidazo[4,5-F]quinoxaline (MeIQx). | Kocaoğlu Cenkci, S. and Kaya, B. 2022. Biology (Basel). 11: PMID: 35453801Presence of 2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline (MeIQx) in dialysate from patients with uremia. | Yanagisawa, H., et al. 1986. Biochem Biophys Res Commun. 138: 1084-9. PMID: 3753488Formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in a model system by heating creatinine, glycine and glucose. | Jägerstad, M., et al. 1984. Mutat Res. 126: 239-44. PMID: 6717461Urinary excretion of 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline in white, black, and Asian men in Los Angeles County. | Ji, H., et al. 1994. Cancer Epidemiol Biomarkers Prev. 3: 407-11. PMID: 7920208Screening of heat-processed Finnish foods for the mutagens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. | Tikkanen, LM., et al. 1993. Food Chem Toxicol. 31: 717-21. PMID: 8225129Characterization of the carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in cooking aerosols under domestic conditions. | Yang, CC., et al. 1998. Carcinogenesis. 19: 359-63. PMID: 9498289
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