Product Name :
2-Amino-2-norbornanecarboxylic acid (CAS 20448-79-7)
Synonym :
2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid; BCH
Application :
2-Amino-2-norbornanecarboxylic acid is An inhibitor of amino acid transport across cell membranes
CAS:
20448-79-7
Purity:
≥97%
Molecular Weight:
155.19
Formula :
C8H13NO2
Physical state:
Solid
solubility :
Soluble in 1N NH4OH (50 mg/ml). BuyFmoc-D-Tyr(3-I)-OH Price of 7-Chloro-L-tryptophan
Shipping Condition :
Store at room temperature
Melting point:
>300° C (lit.)
SMILES:
C1CC2CC1CC2(C(=O)O)N
References:
:Metabolic and ionic coupling factors in amino acid-stimulated insulin release in pancreatic beta-HC9 cells. | Doliba, NM., et al. 2007. Am J Physiol Endocrinol Metab. 292: E1507-19. PMID: 17264232Neutral amino acid transport by isolated small intestinal cells from guinea pigs. | Del Castillo, JR. and Muñiz, R. 1991. Am J Physiol. 261: G1030-6. PMID: 1767844Enhancing effect of zinc on L-histidine transport in rat lung microvascular endothelial cells. | Sakurai, E., et al. 2011. Biol Trace Elem Res. 142: 713-22. PMID: 20721638Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in human prostate cancer. | Okudaira, H., et al. 2011. J Nucl Med. 52: 822-9. PMID: 21536930Synthesis and biological evaluation of ¹⁸F-labeled fluoropropyl tryptophan analogs as potential PET probes for tumor imaging. | Chiotellis, A., et al. 2013. Eur J Med Chem. 70: 768-80. PMID: 24239624Oral and intravenous pharmacokinetics of taurine in sprague-dawley rats: the influence of dose and the possible involvement of the proton-coupled amino acid transporter, PAT1, in oral taurine absorption. | Nielsen, CU., et al. 2017. Physiol Rep. 5: PMID: 29038364Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex. | Yan, R., et al. 2019. Nature. 568: 127-130. PMID: 30867591Regulation of Melanogenesis by the Amino Acid Transporter SLC7A5. | Gaudel, C., et al. 2020. J Invest Dermatol. 140: 2253-2259.e4. PMID: 32240722Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis. | Markowicz-Piasecka, M., et al. 2020. Apoptosis. 25: 426-440. PMID: 32405891Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2. | Fitzgerald, E., et al. 2021. Sci Rep. 11: 9092. PMID: 33907288Thyroid Hormone Transporters in a Human Placental Cell Model. | Chen, Z., et al. 2022. Thyroid. 32: 1129-1137. PMID: 35699060Methylmercury-thiol uptake into cultured brain capillary endothelial cells on amino acid system L. | Mokrzan, EM., et al. 1995. J Pharmacol Exp Ther. 272: 1277-84. PMID: 7891344Glutamine uptake at the blood-brain barrier is mediated by N-system transport. | Ennis, SR., et al. 1998. J Neurochem. 71: 2565-73. PMID: 9832157
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